Serotonin

5-HT4R

cAMP

0.23 nM (5-HT)

N/A

Adrenergic

α 1A AR

Calcium flux

7.47nM(Phenylephrine)

0.29nM (Tamsulosin)

α 1BAR

Calcium flux

4.11nM (Phenylephrine)

6.33nM (Tamsulosin)

α1D AR

Calcium flux

1.94nM (Phenylephrine)

N/A

β1-AR

0.07nM (Isoproterenol)  

 N/A 

β2-AR

Calcium flux

0.045nM (Isoproterenol)

4.84nM (Propranol)

β3-AR

  15.7nM (Isoproterenol)

N/A  

Cannabinoid

CB1R

Calcium flux

2.91nM (CP55940)

17.97nM (Rimonabant)

Ligand-receptor binding

N/A

2.81 nM, Ki=0.77nM (Rimonabant)

CB2R

Calcium flux

8.19nM
(CP55940)

2.64 μM (Rimonabant)

Ligand-receptor binding

N/A

0.81 μM, Ki=0.12 μM (Rimonabant)

Chemokine

CCR1

[ ³⁵ S]GTP γ S binding

CCR2

Calcium flux

8.43 nM (MCP-1)

9.56 nM (TDXX1)

CCR3

[ ³⁵ S]GTP γ S binding

3.11nM (Eotaxin)

N/A

CCR4

[ ³⁵S]GTP γ S binding

7.18nM (MDC)

N/A

CCR5

Calcium flux

4.82nM (RANTES)

3.41nM(TD-0579)

[ ³⁵S]GTP γ S binding

N/A

2.21nM(TD-0579)

CXCR1

[ ³⁵S]GTP γ S binding

9.78nM (IL-8)

N/A

CXCR2

[ ³⁵ S]GTP γ S binding

1nM (IL-8)

N/A

CXCR3

[ ³⁵S]GTP γ S binding

7.47nM (IP-10)

N/A

CXCR4

Calcium flux

18.00nM (SDF-1)

25.26nM(T140)

[ ³⁵S]GTP γ S binding

N/A

2.21nM(T140)

Dopamine

DR-D1

DR-D2

Calcium flux

6.3 nM (Dopamine)

N/A

DR-D5

Calcium flux

0.34nM(Dopamine)

N/A

Glucagon

GCGR

Calcium flux

27.1nM (Glucagon)

26.32nM ([des-His1,Glu9]-Glucagon)

GLP-1R

Calcium flux

1.07nM(GLP-1)

N/A

Luciferase- reporter gene

1.35nM(GLP-1)

N/A

Melanocortin

MCR3

Luciferase- reporter gene

14.78nM (α-MSH)

N/A

MCR4

Luciferase- reporter gene

6.05nM (α-MSH)

N/A

Melatonin

MT1R

Ligand-receptor binding

1.95nM, Ki=1.94nM (Melatonin)

N/A

MT2R

Ligand-receptor binding

4.16nM, Ki=4.14nM (Melatonin)

N/A

Metabotropic glutamate

mGLu2

mGLu3

Opioid

DOR

Calcium flux

4.0nM(DPDPE)

1.6nM (Naltrindole)

Ligand-receptor binding

N/A

1.7nM, Ki=0.8nM (Naltrindole)

MOR

Calcium flux

3.6nM(DAGO)

2.6nM (β-Funaltrexamine)

KOR

Calcium flux

0.6nM(U50488)

13.5nM(Naloxone)

ION CHANNEL

K +

hERG